Article
Presence of CD8+ T cells in the ectocervical mucosa correlates with genital viral shedding in HIV-infected women despite a low prevalence of HIV RNA-expressing cells in the tissue.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2014
Gibbs Anna, Hirbod Taha, Li Qingsheng, Bohman Karin, Ball Terry B, Plummer Francis A, Kaul Rupert, Kimani Joshua, Broliden Kristina, Tjernlund Annelie
Abstract excerpt
The female genital tract is a portal of entry for sexual HIV transmission and a possible viral reservoir. In this study, the ectocervical CD8+ T cell distribution was explored in situ and was related to expression of CD3 and HLA-DR and presence of HIV RNA. For this purpose, ectocervical tissue sa...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.