Article
Depletion and activation of mucosal CD4 T cells in HIV infected women with HPV-associated lesions of the cervix uteri.
PloS one - 1 Jan 2020
Mbuya Wilbert, Mcharo Ruby, Mhizde Jacklina, Mnkai Jonathan, Mahenge Anifrid, Mwakatima Maria, Mwalongo Wolfram, Chiwerengo Nhamo, Hölscher Michael, Lennemann Tessa, Saathoff Elmar, Rwegoshora France, Torres Liset, Kroidl Arne, Geldmacher Christof, Held Kathrin, Chachage Mkunde
Abstract excerpt
BACKGROUND: The burden of HPV-associated premalignant and malignant cervical lesions remains high in HIV+ women even under ART treatment. In order to identify possible underlying pathophysiologic mechanisms, we studied activation and HIV co-receptor expression in cervical T-cell populations in relation to HIV, HPV and cervical lesion status. METHODS: Cervical cytobrush (n = 468: 253 HIV- and 215 HIV+; 71% on ART)...
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