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Article

NKp46+ CD3+ cells: a novel nonconventional T cell subset in cattle exhibiting both NK cell and T cell features.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2014

Connelley Timothy K, Longhi Cassandra, Burrells Alison, Degnan Kathryn, Hope Jayne, Allan Alasdair J, Hammond John A, Storset Anne K, Morrison W Ivan

Abstract excerpt

The NKp46 receptor demonstrates a high degree of lineage specificity, being expressed almost exclusively in NK cells. Previous studies have demonstrated NKp46 expression by T cells, but NKp46+ CD3+ cells are rare and almost universally associated with NKp46 acquisition by T cells following stimulation. In this study we demonstrate the existence of a population of NKp46+ CD3+ cells resident in normal bovine PBMCs...

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Cattle Diseases
CD3 Complex
Cytotoxicity, Immunologic
Receptors, Antigen, T-Cell
Receptors, Natural Killer Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocyte Subsets

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Identifiers

PMID: 24639352
DOI: 10.4049/jimmunol.1302464
PMCID: PMC3990274

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