Article
Decision-making on preimplantation genetic diagnosis and prenatal diagnosis: a challenge for couples with hereditary breast and ovarian cancer.
Human reproduction (Oxford, England) - 1 May 2014
Derks-Smeets I A P, Gietel-Habets J J G, Tibben A, Tjan-Heijnen V C G, Meijer-Hoogeveen M, Geraedts J P M, van Golde R, Gomez-Garcia E, van den Bogaart E, van Hooijdonk M, de Die-Smulders C E M, van Osch L A D M
Abstract excerpt
STUDY QUESTION: How do couples with a BRCA1/2 mutation decide on preimplantation genetic diagnosis (PGD) and prenatal diagnosis (PND) for hereditary breast and ovarian cancer syndrome (HBOC)? SUMMARY ANSWER: BRCA couples primarily classify PGD and/or PND as reproductive options based on the perceived severity of HBOC and moral considerations, and consequently weigh the few important advantages of PGD against...
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