Article
Genomic variation in macrophage-cultured European porcine reproductive and respiratory syndrome virus Olot/91 revealed using ultra-deep next generation sequencing.
Virology journal - 4 Mar 2014
Lu Zen H, Brown Alexander, Wilson Alison D, Calvert Jay G, Balasch Monica, Fuentes-Utrilla Pablo, Loecherbach Julia, Turner Frances, Talbot Richard, Archibald Alan L, Ait-Ali Tahar
Abstract excerpt
BACKGROUND: Porcine Reproductive and Respiratory Syndrome (PRRS) is a disease of major economic impact worldwide. The etiologic agent of this disease is the PRRS virus (PRRSV). Increasing evidence suggest that microevolution within a coexisting quasispecies population can give rise to high sequence heterogeneity in PRRSV. FINDINGS: We developed a pipeline based on the ultra-deep next generation sequencing...
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