Article
Culture of primary ciliary dyskinesia epithelial cells at air-liquid interface can alter ciliary phenotype but remains a robust and informative diagnostic aid.
PloS one - 1 Jan 2014
Hirst Robert A, Jackson Claire L, Coles Janice L, Williams Gwyneth, Rutman Andrew, Goggin Patricia M, Adam Elizabeth C, Page Anthony, Evans Hazel J, Lackie Peter M, O'Callaghan Christopher, Lucas Jane S
Abstract excerpt
BACKGROUND: The diagnosis of primary ciliary dyskinesia (PCD) requires the analysis of ciliary function and ultrastructure. Diagnosis can be complicated by secondary effects on cilia such as damage during sampling, local inflammation or recent infection. To differentiate primary from secondary abnormalities, re-analysis of cilia following culture and re-differentiation of epithelial cells at an air-liquid...
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