Fisher's geometrical model emerges as a property of complex integrated phenotypic networks.

Abstract excerpt

Models relating phenotype space to fitness (phenotype-fitness landscapes) have seen important developments recently. They can roughly be divided into mechanistic models (e.g., metabolic networks) and more heuristic models like Fisher's geometrical model. Each has its own drawbacks, but both yield testable predictions on how the context (genomic background or environment) affects the distribution of mutation...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Evolution, Molecular
• Share to Genetic Fitness
• Share to Models, Genetic