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Article

Dynamics associated with spontaneous differentiation of ovarian stem cells in vitro

25 Feb 2014

Abstract excerpt

BACKGROUND: Recent studies suggest that ovarian germ line stem cells replenish oocyte-pool in adult stage, and challenge the central doctrine of 'fixed germ cell pool' in mammalian reproductive biology. Two distinct populations of spherical stem cells with high nucleo-cytoplasmic ratio have been recently identified in the adult mammalian ovary surface epithelium (OSE) including nuclear OCT-4A positive very small...

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PMID: 24568237
DOI: 10.1186/1757-2215-7-25

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