Article
Microevolution during an Anthrax outbreak leading to clonal heterogeneity and penicillin resistance.
PloS one - 1 Jan 2014
Ågren Joakim, Finn Maria, Bengtsson Björn, Segerman Bo
Abstract excerpt
Anthrax is a bacterial disease primarily affecting grazing animals but it can also cause severe disease in humans. We have used genomic epidemiology to study microevolution of the bacterium in a confined outbreak in cattle which involved emergence of an antibiotic-resistant phenotype. At the time of death, the animals contained a heterogeneous population of Single Nucleotide Variants (SNVs), some being clonal but...
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