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Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology

11 Feb 2014

Abstract excerpt

We sought to define whether there are intrinsic molecular subtypes of high-grade bladder cancer. Consensus clustering performed on gene expression data from a meta-dataset of high-grade, muscle-invasive bladder tumors identified two intrinsic, molecular subsets of high-grade bladder cancer, termed "luminal" and "basal-like," which have characteristics of different stages of urothelial differentiation, reflect the...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 24520177
DOI: 10.1073/pnas.1318376111

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