Article
An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride.
Critical reviews in toxicology - 1 Apr 2014
Pottenger Lynn H, Andrews Larry S, Bachman Ammie N, Boogaard Peter J, Cadet Jean, Embry Michelle R, Farmer Peter B, Himmelstein Matthew W, Jarabek Annie M, Martin Elizabeth A, Mauthe Robert J, Persaud Rudranath, Preston R Julian, Schoeny Rita, Skare Julie, Swenberg James A, Williams Gary M, Zeiger Errol, Zhang Fagen, Kim James H
Abstract excerpt
The framework analysis previously presented for using DNA adduct information in the risk assessment of chemical carcinogens was applied in a series of case studies which place the adduct information into context with the key events in carcinogenesis to determine whether they could be used to support a mutagenic mode of action (MOA) for the examined chemicals. Three data-rich chemicals, aflatoxin B1 (AFB1),...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.