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Article

Aquaporin‐1 Promoter Hypermethylation Is Associated with Improved Prognosis in Salivary Gland Adenoid Cystic Carcinoma

3 Feb 2014

Abstract excerpt

OBJECTIVES: Aquaporin-1 (AQP1) is a candidate oncogene that is epigenetically modified in adenoid cystic carcinoma (ACC). We sought to (1) assess AQP1 promoter methylation and expression in an ACC cohort, (2) identify correlations between AQP1 and clinical outcomes, and (3) explore the role of AQP1 in tumor progression in vitro. STUDY DESIGN: Laboratory study, retrospective chart review. SETTING: Academic medical...

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PMID: 24493792
DOI: 10.1177/0194599814521569

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