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Article

A New Multicolor Bioluminescence Imaging Platform to Investigate NF-κB Activity and Apoptosis in Human Breast Cancer Cells

17 Jan 2014

Abstract excerpt

BACKGROUND: Evaluation of novel drugs for clinical development depends on screening technologies and informative preclinical models. Here we developed a multicolor bioluminescent imaging platform to simultaneously investigate transcription factor NF-κB signaling and apoptosis. METHODS: The human breast cancer cell line (MDA-MB-231) was genetically modified to express green, red and blue light emitting luciferases...

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PMID: 24465597
DOI: 10.1371/journal.pone.0085550

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