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Article

Requirement of enhanced Survival Motoneuron protein imposed during neuromuscular junction maturation.

The Journal of clinical investigation - 1 Feb 2014

Kariya Shingo, Obis Teresa, Garone Caterina, Akay Turgay, Sera Fusako, Iwata Shinichi, Homma Shunichi, Monani Umrao R

Abstract excerpt

Spinal muscular atrophy is a common motor neuron disease caused by low survival motoneuron (SMN), a key protein in the proper splicing of genes. Restoring the protein is therefore a promising therapeutic strategy. Implementation of this strategy, however, depends on defining the temporal requirements for SMN. Here, we used controlled knockdown of SMN in transgenic mice to determine the precise postnatal stage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24463453
DOI: 10.1172/JCI72017
PMCID: PMC3904626

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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