Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SMAD3 gene variant is a risk factor for recurrent surgery in patients with Crohn's disease.

Journal of Crohn's & colitis - 1 Aug 2014

Fowler Sharyle A, Ananthakrishnan Ashwin N, Gardet Agnes, Stevens Christine R, Korzenik Joshua R, Sands Bruce E, Daly Mark J, Xavier Ramnik J, Yajnik Vijay

Abstract excerpt

BACKGROUND AND AIMS: More than 80% of Crohn's disease (CD) patients will require surgery. Surgery is not curative and rates of re-operation are high. Identification of genetic variants associated with repeat surgery would allow risk stratification of patients who may benefit from early aggressive therapy and/or post-operative prophylactic treatment. METHODS: CD patients who had at least one CD-related bowel...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child, Preschool
Share to Crohn Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotyping Techniques

Share to Kaplan-Meier Estimate

Share to Registries

Share to Reoperation

Share to Smad3 Protein

Share to Smoking Cessation

Source

Open in PubMed Open full text

Identifiers

PMID: 24461721
DOI: 10.1016/j.crohns.2014.01.003
PMCID: PMC4237062

Genes

SMAD3
NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SMAD3 gene variant is a risk factor for recurrent surgery in patients with Crohn's disease.PMID 24461721Read ↗

CARD8 gene variant is a risk factor for recurrent surgery in patients with Crohn's disease.Semantic proximity Read ↗

Penetrating or stricturing diseases are the major determinants of time to first and repeat resection surgery in Crohn's disease.Semantic proximity Read ↗

A BACH2 Gene Variant Is Associated with Postoperative Recurrence of Crohn's Disease.Semantic proximity Read ↗

Postsurgical recurrence of ileal Crohn's disease: an update on risk factors and intervention points to a central role for impaired host-microflora homeostasis.Semantic proximity Read ↗

Risk factors for repetitive ileocolic resection in patients with Crohn's disease: results of an observational cohort study.Semantic proximity Read ↗

Clinical and Genetic Factors Impact Time to Surgical Recurrence After Ileocolectomy for Crohn's Disease.Semantic proximity Read ↗

Stricturing phenotype is associated with an increased risk of postoperative surgical recurrence in isolated small bowel Crohn's disease.Semantic proximity Read ↗

Pathogenesis of postoperative recurrence in Crohn's disease.Semantic proximity Read ↗

Disease reprogression following surgical resection in Crohn disease.Semantic proximity Read ↗

CARD15 gene variants and risk of reoperation in Crohn's disease patients.Semantic proximity Read ↗

NOD2 gene variant is a risk factor for postoperative complications in patients with Crohn's disease: A genetic association study.Semantic proximity Read ↗

The influence of CTGF single-nucleotide polymorphisms on outcomes in Crohn's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.