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Induction of Virulence Gene Expression in Staphylococcus aureus by Pulmonary Surfactant

23 Jan 2014

Abstract excerpt

We performed a genomewide analysis using a next-generation sequencer to investigate the effect of pulmonary surfactant on gene expression in Staphylococcus aureus, a clinically important opportunistic pathogen. RNA sequence (RNA-seq) analysis of bacterial transcripts at late log phase revealed 142 genes that were upregulated >2-fold following the addition of pulmonary surfactant to the culture medium. Among these...

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PMID: 24452679
DOI: 10.1128/iai.01635-13

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