Article
Do orofacial clefts represent different genetic entities?
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association - 1 Jan 2015
Reiter Rudolf, Brosch Sibylle, Lüdeke Manuel, Fischbein Elena, Rinckleb Antje, Haase Stephan, Schwandt Anke, Pickhard Anja, Maier Christiane, Högel Josef, Vogel Walther
Abstract excerpt
OBJECTIVE: To contribute to the understanding of potential genetic differences between different cleft types. METHOD: Analysis of family history concerning cleft type and search for cleft-type-specific associations in candidate genes performed in 98 individuals from 98 families. RESULTS: In a given family, the cleft type of a second case was more often identical to the index case than expected by chance. Each...
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