HPV16 E6*II gene expression in intraepithelial cervical lesions as an indicator of neoplastic grade: a pilot study.

doi:10.1007/s12032-014-0842-6

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Article

HPV16 E6*II gene expression in intraepithelial cervical lesions as an indicator of neoplastic grade: a pilot study.

Medical oncology (Northwood, London, England) - 1 Mar 2014

Pastuszak-Lewandoska Dorota, Bartosińska-Dyc Anna, Migdalska-Sęk Monika, Czarnecka Karolina H, Nawrot Ewa, Domańska Daria, Szyłło Krzysztof, Brzeziańska Ewa

Abstract excerpt

Integration of the HPV genome into a host cell DNA leads to the deregulated overexpression of the viral E6 and E7 oncoproteins, and this is a key factor for progression from low-grade cervical lesions to high-grade lesions and invasive cervical cancer. The aim of our study was to analyze the expression levels of HPV E6*I/E6*II and E7 genes in cervical neoplasia of different grades. The analysis involved 10...

Topics

Adult
Aged
Carcinoma, Squamous Cell
Case-Control Studies
Cervix Uteri
DNA, Viral
Female
Follow-Up Studies
Genotype
Human papillomavirus 16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Middle Aged

Neoplasm Grading

Oncogene Proteins, Viral

Papillomavirus Infections

Pilot Projects

Prognosis

RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 24436016
DOI: 10.1007/s12032-014-0842-6

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