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Article

Proteomic and functional consequences of hexokinase deficiency in glucose-repressible Kluyveromyces lactis.

Molecular & cellular proteomics : MCP - 1 Mar 2014

Mates Nadia, Kettner Karina, Heidenreich Falk, Pursche Theresia, Migotti Rebekka, Kahlert Günther, Kuhlisch Eberhard, Breunig Karin D, Schellenberger Wolfgang, Dittmar Gunnar, Hoflack Bernard, Kriegel Thomas M

Abstract excerpt

The analysis of glucose signaling in the Crabtree-positive eukaryotic model organism Saccharomyces cerevisiae has disclosed a dual role of its hexokinase ScHxk2, which acts as a glycolytic enzyme and key signal transducer adapting central metabolism to glucose availability. In order to identify evolutionarily conserved characteristics of hexokinase structure and function, the cellular response of the...

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Identifiers

PMID: 24434903
DOI: 10.1074/mcp.M113.032714
PMCID: PMC3945914

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Source receipt: pubmed, retrieved 7 Sept 2026.

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