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Article

Outcome-based determination of optimal pyrosequencing assay for MGMT methylation detection in glioblastoma patients

13 Jan 2014

Abstract excerpt

The methylation of O(6)-methylguanine DNA methyltransferase (MGMT) gene promoter is a key biological marker in clinical neuro-oncology. Nevertheless, there is no consensus concerning the best technique for its assessment. In a recent study comparing five methods to analyze MGMT status, we found that the best prediction of survival was obtained with a pyrosequencing (PSQ) test assessing methylation of 5 CpGs (CpGs...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 24420923
DOI: 10.1007/s11060-013-1332-y

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