Article
Heteropathogenic virulence and phylogeny reveal phased pathogenic metamorphosis in Escherichia coli O2:H6.
EMBO molecular medicine - 1 Mar 2014
Bielaszewska Martina, Schiller Roswitha, Lammers Lydia, Bauwens Andreas, Fruth Angelika, Middendorf Barbara, Schmidt M Alexander, Tarr Phillip I, Dobrindt Ulrich, Karch Helge, Mellmann Alexander
Abstract excerpt
Extraintestinal pathogenic and intestinal pathogenic (diarrheagenic) Escherichia coli differ phylogenetically and by virulence profiles. Classic theory teaches simple linear descent in this species, where non-pathogens acquire virulence traits and emerge as pathogens. However, diarrheagenic Shiga toxin-producing E. coli (STEC) O2:H6 not only possess and express virulence factors associated with diarrheagenic and...
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