Article
Proliferation and survival signaling from both Jak2-V617F and Lyn involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 cell line newly established from acute myeloid leukemia transformed from polycythemia vera.
PloS one - 1 Jan 2014
Nagao Toshikage, Kurosu Tetsuya, Umezawa Yoshihiro, Nogami Ayako, Oshikawa Gaku, Tohda Shuji, Yamamoto Masahide, Miura Osamu
Abstract excerpt
The gain of function mutation JAK2-V617F is very frequently found in myeloproliferative neoplasms (MPNs) and is strongly implicated in pathogenesis of these and other hematological malignancies. Here we report establishment of a new leukemia cell line, PVTL-1, homozygous for JAK2-V617F from a 73-...
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