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Article

BRD4 associates with p53 in DNMT3A-mutated leukemia cells and is implicated in apoptosis by the bromodomain inhibitor JQ1.

Cancer medicine - 1 Dec 2013

Stewart Helen Jayne Susan, Horne Gillian Abigail, Bastow Sarah, Chevassut Timothy James Telfer

Abstract excerpt

The bromodomain and extra terminal (BET) family protein bromodomain containing protein 4 (BRD4) is an epigenetic regulator recently identified as a therapeutic target for several hematological cancers, notably mixed lineage leukemia-fusion acute myeloid leukemia (MLL-AML). Here, we show that the...

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Source

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Identifiers

PMID: 24403256
DOI: 10.1002/cam4.146
PMCID: PMC3892387

Genes

BRD4
NPM1
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24403256-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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