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Article

BET Bromodomain Inhibition of <i>MYC</i> -Amplified Medulloblastoma

2 Dec 2013

Abstract excerpt

PURPOSE: MYC-amplified medulloblastomas are highly lethal tumors. Bromodomain and extraterminal (BET) bromodomain inhibition has recently been shown to suppress MYC-associated transcriptional activity in other cancers. The compound JQ1 inhibits BET bromodomain-containing proteins, including BRD4. Here, we investigate BET bromodomain targeting for the treatment of MYC-amplified medulloblastoma. EXPERIMENTAL...

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PMID: 24297863
DOI: 10.1158/1078-0432.ccr-13-2281

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