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Article

Phenotype correction of hemophilia A mice with adeno-associated virus vectors carrying the B domain-deleted canine factor VIII gene.

Thrombosis research - 1 Jan 2006

Ishiwata Akira, Mimuro Jun, Kashiwakura Yuji, Niimura Masanori, Takano Katsuhiro, Ohmori Tsukasa, Madoiwa Seiji, Mizukami Hiroaki, Okada Takashi, Naka Hiroyuki, Yoshioka Akira, Ozawa Keiya, Sakata Yoichi

Abstract excerpt

Adeno-associated virus (AAV) vectors carrying the B domain-deleted canine FVIII (BDD cFVIII) gene utilizing the beta-actin minimum promoter (167b) pseudotyped with serotype 1 (AAV1-beta-actin-cFVIII) and serotype 8 (AAV8-beta-actin-cFVIII) were developed to express cFVIII in hemophilia A mice. FVIII clotting activities measured by the APTT method increased in hemophilia A mice with intramuscular injection of...

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PMID: 16371232
DOI: 10.1016/j.thromres.2005.11.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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