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Article

A Single Subexcitation‐Energy Electron Can Induce a Double‐Strand Break in DNA Modified by Platinum Chemotherapeutic Drugs

4 Dec 2013

Abstract excerpt

The sensitization of malignant cells to ionizing radiation is the clinical rationale for the use of platinum-drug-based concurrent chemoradiotherapy (CCRT) for cancer treatment; however, the specific mechanisms of radiosensitization and their respective contributions still remain unknown. Biological mechanisms such as inhibition of DNA repair may contribute to the efficacy of CCRT; nevertheless, there is a dearth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 24376113
DOI: 10.1002/cmdc.201300462

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