Article
Molecular determinants defining the triggering range of prefusion F complexes of canine distemper virus.
Journal of virology - 1 Mar 2014
Avila Mislay, Alves Lisa, Khosravi Mojtaba, Ader-Ebert Nadine, Origgi Francesco, Schneider-Schaulies Jürgen, Zurbriggen Andreas, Plemper Richard K, Plattet Philippe
Abstract excerpt
UNLABELLED: The morbillivirus cell entry machinery consists of a fusion (F) protein trimer that refolds to mediate membrane fusion following receptor-induced conformational changes in its binding partner, the tetrameric attachment (H) protein. To identify molecular determinants that control F refolding, we generated F chimeras between measles virus (MeV) and canine distemper virus (CDV). We located a central...
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