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Article

Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development

19 Dec 2013

Abstract excerpt

Mesangial cells are specialized pericyte/smooth muscle cells that surround and constrain the vascular network within the glomerulus of the kidney. They are derived from the stromal mesenchyme, a progenitor population distinct from nephron stem cells. Whether mesangial cells have a distinct origin from vascular smooth muscle cells (VSMCs) and the pathways that govern their specification are unknown. Here we show...

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PMID: 24353058
DOI: 10.1242/dev.100271

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