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Article

The mechanism of heterogeneous beta-lactam resistance in MRSA: key role of the stringent stress response.

PloS one - 1 Jan 2013

Kim Choonkeun, Mwangi Michael, Chung Marilyn, Milheiriço Catarina, Milheirço Catarina, de Lencastre Herminia, Tomasz Alexander

Abstract excerpt

All methicillin resistant S. aureus (MRSA) strains carry an acquired genetic determinant--mecA or mecC--which encode for a low affinity penicillin binding protein -PBP2A or PBP2A'--that can continue the catalysis of peptidoglycan transpeptidation in the presence of high concentrations of beta-lactam antibiotics which would inhibit the native PBPs normally involved with the synthesis of staphylococcal cell wall...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Bacterial

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Source

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Identifiers

PMID: 24349368
DOI: 10.1371/journal.pone.0082814
PMCID: PMC3857269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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