Article
Prolidase deficiency breaks tolerance to lupus-associated antigens.
International journal of rheumatic diseases - 1 Dec 2013
Kurien Biji T, D'Sousa Anil, Bruner Benjamin F, Gross Timothy, James Judith A, Targoff Ira N, Maier-Moore Jacen S, Harley Isaac T W, Wang Heng, Scofield R Hal
Abstract excerpt
AIM: Prolidase deficiency is a rare autosomal recessive disease in which one of the last steps of collagen metabolism, cleavage of proline-containing dipeptides, is impaired. Only about 93 patients have been reported with about 10% also having systemic lupus erythematosus (SLE). METHODS: We studied a large extended Amish pedigree with four prolidase deficiency patients and three heterozygous individuals for...
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