Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel outbred mouse model of 2009 pandemic influenza and bacterial co-infection severity.

PloS one - 1 Jan 2013

McHugh Kevin J, Mandalapu Sivanarayana, Kolls Jay K, Ross Ted M, Alcorn John F

Abstract excerpt

Influenza viruses pose a significant health risk and annually impose a great cost to patients and the health care system. The molecular determinants of influenza severity, often exacerbated by secondary bacterial infection, are largely unclear. We generated a novel outbred mouse model of influenza virus, Staphylococcus aureus, and co-infection utilizing influenza A/CA/07/2009 virus and S. aureus (USA300). Outbred...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Outbred Strains
Share to Bacterial Load
Share to Coinfection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza A virus

Share to Influenza A Virus, H1N1 Subtype

Share to Orthomyxoviridae Infections

Share to Pneumonia

Share to Weight Loss

Source

Open in PubMed Open full text

Identifiers

PMID: 24324838
DOI: 10.1371/journal.pone.0082865
PMCID: PMC3855784

Genes

TNF
CXCL10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel outbred mouse model of 2009 pandemic influenza and bacterial co-infection severity.PMID 24324838Read ↗

Heterotypic Influenza Infections Mitigate Susceptibility to Secondary Bacterial InfectionSemantic proximity Read ↗

Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice.Semantic proximity Read ↗

Host immune responses associated with SARS-CoV-2 Omicron infection result in protection or pathology during reinfection depending on mouse genetic background.Semantic proximity Read ↗

B.1.1.7 and B.1.351 variants are highly virulent in K18-ACE2 transgenic mice and show different pathogenic patterns from early SARS-CoV-2 strainsSemantic proximity Read ↗

Integrated analysis of mRNA-seq and miRNA-seq for host susceptibilities to influenza A (H7N9) infection in inbred mouse lines.Semantic proximity Read ↗

Differential Host Determinants Contribute to the Pathogenesis of 2009 Pandemic H1N1 and Human H5N1 Influenza A Viruses in Experimental Mouse ModelsSemantic proximity Read ↗

Modeling Infectious Disease in Mice: Co-Adaptation and the Role of Host-Specific IFNγ ResponsesSemantic proximity Read ↗

A C57BL/6 Mouse Model of SARS-CoV-2 Infection Recapitulates Age- and Sex-Based Differences in Human COVID-19 Disease and RecoverySemantic proximity Read ↗

Differential Responses of Lung and Intestinal Microbiota to SARS-CoV-2 Infection: A Comparative Study of the Wuhan and Omicron Strains in K18-hACE2 tg MiceSemantic proximity Read ↗

A C57BL/6 Mouse model of SARS-CoV-2 infection recapitulates age- and sex-based differences in human COVID-19 disease and recoverySemantic proximity Read ↗

SARS-CoV-2 variants induce distinct disease and impact in the bone marrow and thymus of miceSemantic proximity Read ↗

The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replicationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.