Article
HLA and non-HLA genes in Behçet's disease: a multicentric study in the Spanish population.
Arthritis research & therapy - 4 Oct 2013
Montes-Cano Marco Antonio, Conde-Jaldón Marta, García-Lozano José Raul, Ortiz-Fernández Lourdes, Ortego-Centeno Norberto, Castillo-Palma María Jesús, Espinosa Gerard, Graña-Gil Genaro, González-Gay Miguel Angel, Barnosi-Marín Ana Celia, Solans Roser, Fanlo Patricia, Camps Teresa, Castañeda Santos, Sánchez-Bursón Juan, Núñez-Roldán Antonio, Martín Javier, González-Escribano María Francisca
Abstract excerpt
INTRODUCTION: According to genome wide association (GWA) studies as well as candidate gene approaches, Behçet's disease (BD) is associated with human leukocyte antigen (HLA)-A and HLA-B gene regions. The HLA-B51 has been consistently associated with the disease, but the role of other HLA class I molecules remains controversial. Recently, variants in non-HLA genes have also been associated with BD. The aims of...
Topics
- Adult
- Behcet Syndrome
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotype
- HLA Antigens