Article
[Kras oncogene and pancreatic cancer: thirty years after].
Medecine sciences : M/S - 1 Nov 2013
Bournet Barbara, Dufresne Marlène, Selves Janick, Torrisani Jérôme, Cordelier Pierre, Buscail Louis
Abstract excerpt
Point mutations of the Kras oncogene induce in cancerous cells an uncontrolled increase of cell proliferation and invasiveness. Mutation of Kras appears early during the process of the pancreatic carcinogenesis and is the most frequent genetic alteration in pancreatic adenocarcinoma (75 to 95 % of cases) as well as in precancerous lesions such as PanIN and IMPN. These latter lesions and tumour microenvironment...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.