[Genetic and molecular basis for sodium channel-mediated Brugada syndrome].

Abstract excerpt

Brugada syndrome is a genetic disease that is characterized by abnormal electrocardiogram findings and an increased risk of sudden cardiac death. This syndrome is linked to mutations in the SCN5A gene in approximately 20% of Brugada syndrome probands. SCN5A encodes the α subunit of the cardiac sodium channel. Studies conducted over the past decade have identified 11 other Brugada syndrome susceptibility genes...

Topics

• Brugada Syndrome
• Humans
• Male
• Mutation
• NAV1.5 Voltage-Gated Sodium Channel
• Pedigree