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IL-17 Inhibits Chondrogenic Differentiation of Human Mesenchymal Stem Cells

15 Nov 2013

Abstract excerpt

OBJECTIVE: Mesenchymal stem cells (MSCs) can differentiate into cells of mesenchymal lineages, such as osteoblasts and chondrocytes. Here we investigated the effects of IL-17, a key cytokine in chronic inflammation, on chondrogenic differentiation of human MSCs. METHODS: Human bone marrow MSCs were pellet cultured in chondrogenic induction medium containing TGF-β3. Chondrogenic differentiation was detected by...

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PMID: 24260226
DOI: 10.1371/journal.pone.0079463

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