Article
Pharmacological targeting in inherited arrhythmia syndromes.
Current medicinal chemistry - 1 Jan 2014
Zumhagen S, Strutz-Seebohm N, Seebohm G, Schulze-Bahr E
Abstract excerpt
The development of pharmacologic agents for the treatment of diseases is still challenging, especially in rare inherited arrhythmia syndromes like long and short QT syndrome, Brugada syndrome and catecholaminergic polymorphic ventricular tachycardia. The underling pathophysiologic mechanism of these inherited diseases is in most cases either a gain- or a loss-of-function due to mutations in ion channel genes....
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