Article
A new and improved method based on polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) for the determination of A1298C mutation in the methylenetetrahydrofolate reductase (MTHFR) gene.
Annals of clinical and laboratory science - 1 Jan 2013
Machnik Grzegorz, Zapala Malgorzata, Pelc Ewa, Gasecka-Czapla Monika, Kaczmarczyk Grzegorz, Okopien Boguslaw
Abstract excerpt
Intracellular folate homeostasis and metabolism is regulated by numerous genes. Among them, 5,10-methylenetetrahydrofolate reductase (MTHFR) is of special interest because of its involvement in regulation of the homocysteine level in the body as a result of folate metabolism. Moreover, some studies demonstrated that the homocysteine plasma level in individuals may be influenced by polymorphisms present in the...
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