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Pediatric Fecal Microbiota Harbor Diverse and Novel Antibiotic Resistance Genes

13 Nov 2013

Abstract excerpt

Emerging antibiotic resistance threatens human health. Gut microbes are an epidemiologically important reservoir of resistance genes (resistome), yet prior studies indicate that the true diversity of gut-associated resistomes has been underestimated. To deeply characterize the pediatric gut-associated resistome, we created metagenomic recombinant libraries in an Escherichia coli host using fecal DNA from 22...

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PMID: 24236055
DOI: 10.1371/journal.pone.0078822

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