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Article

Genetic variants related to gap junctions and hormone secretion influence conception rates in cows.

Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 2013

Sugimoto Mayumi, Sasaki Shinji, Gotoh Yusaku, Nakamura Yuuki, Aoyagi Yoshito, Kawahara Takayoshi, Sugimoto Yoshikazu

Abstract excerpt

The recent decline in fertility is a serious problem in the dairy industry. To overcome this problem, we performed a genome-wide association study using 384 Holsteins and identified four loci associated with conception rates. Two of them contained gap junction-related genes: PKP2 and CTTNBP2NL. Further analysis confirmed that PKP2 increased connexin 43, a gap junction protein, whereas CTTNBP2NL dephosphorylated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24218568
DOI: 10.1073/pnas.1309307110
PMCID: PMC3845116

Genes

PKP2
CACNB2
SETD6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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