Article
Absence of KHDC3L mutations in Chinese patients with recurrent and sporadic hydatidiform moles.
Cancer genetics - 1 Jan 2000
Zhao Wei, Muhetaer Alanuer, Luo TengFei, Zhou Wei, Qi Cheng, Chen XiaoDuan, Zhang XiaoFei, Zhang ZhiFen, Dery Christine, Slim Rima, Qian JianHua
Abstract excerpt
To date, two maternal-effect genes have been shown to play causal roles in recurrent hydatidiform moles (RHMs). NLRP7, a major gene for this condition, codes for a nucleotide-binding oligomerization domain-like receptor and is mutated in 48 to 60% of patients with RHMs. KHDC3L is a recently identified gene that is mutated in 14% of NLRP7-negative patients. We screened KHDC3L for mutations in a total of 101...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.