Article
Evidence of positive selection for a glycogen synthase (GYS1) mutation in domestic horse populations.
The Journal of heredity - 1 Jan 2000
McCoy Annette M, Schaefer Robert, Petersen Jessica L, Morrell Peter L, Slamka Megan A, Mickelson James R, Valberg Stephanie J, McCue Molly E
Abstract excerpt
A dominantly inherited gain-of-function mutation in the glycogen synthase (GYS1) gene, resulting in excess skeletal muscle glycogen, has been identified in more than 30 horse breeds. This mutation is associated with the disease Equine Polysaccharide Storage Myopathy Type 1, yet persists at high frequency in some breeds. Under historical conditions of daily work and limited feed, excess muscle glycogen may have...
Topics
- Alleles
- Animals
- Breeding
- Genetic Predisposition to Disease
- Glycogen
- Glycogen Storage Disease
- Glycogen Synthase
- Haplotypes
- Homozygote
- Horse Diseases
- Horses
- Muscle, Skeletal
- Mutation
- Selection, Genetic