Article
Transfer of specificity by murine alpha and beta T-cell receptor genes.
Nature - 1 Jan 2000
Dembić Z, Haas W, Weiss S, McCubrey J, Kiefer H, von Boehmer H, Steinmetz M
Abstract excerpt
T-cell receptor alpha- and beta-chain genes were isolated from a class I major histocompatibility complex-restricted cytotoxic T-cell clone and transferred by protoplast fusion into another cytolytic T-cell clone of different specificity. Expression of the transfected alpha and beta genes endowed the recipient cell with the specificity of the donor cell.
Topics
- Alleles
- Animals
- Bacteriophage lambda
- Base Sequence
- Cell Line
- Clone Cells
- DNA, Recombinant
- Histocompatibility Antigens
- Hybridomas
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA