Article
Relation between genotype and left-ventricular dilatation in patients with Marfan syndrome.
Gene - 15 Jan 2014
Aalberts Jan J J, van Tintelen J Peter, Meijboom Lilian J, Polko Annette, Jongbloed Jan D H, van der Wal Henriette, Pals Gerard, Osinga Jan, Timmermans Janneke, de Backer Julie, Bakker Marian K, van Veldhuisen Dirk J, Hofstra Robert M W, Mulder Barbara J M, van den Berg Maarten P
Abstract excerpt
Cardiovascular manifestations in patients with Marfan syndrome (MFS) are related to aortic and valvular abnormalities. However, dilatation of the left ventricle (LV) can occur, even in the absence of aortic surgery or valvular abnormalities. We evaluated genetic characteristics of patients with MFS with LV dilatation. One hundred eighty-two patients fulfilling the MFS criteria, without valvular abnormalities or...
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