Article
Candidate genetic pathways for attention-deficit/hyperactivity disorder (ADHD) show association to hyperactive/impulsive symptoms in children with ADHD.
Journal of the American Academy of Child and Adolescent Psychiatry - 1 Nov 2013
Bralten Janita, Franke Barbara, Waldman Irwin, Rommelse Nanda, Hartman Catharina, Asherson Philip, Banaschewski Tobias, Ebstein Richard P, Gill Michael, Miranda Ana, Oades Robert D, Roeyers Herbert, Rothenberger Aribert, Sergeant Joseph A, Oosterlaan Jaap, Sonuga-Barke Edmund, Steinhausen Hans-Christoph, Faraone Stephen V, Buitelaar Jan K, Arias-Vásquez Alejandro
Abstract excerpt
OBJECTIVE: Because multiple genes with small effect sizes are assumed to play a role in attention-deficit/hyperactivity disorder (ADHD) etiology, considering multiple variants within the same analysis likely increases the total explained phenotypic variance, thereby boosting the power of genetic studies. This study investigated whether pathway-based analysis could bring scientists closer to unraveling the biology...
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