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Article

Positive selection in bone morphogenetic protein 15 targets a natural mutation associated with primary ovarian insufficiency in human.

PloS one - 1 Jan 2013

Auclair Sylvain, Rossetti Raffaella, Meslin Camille, Monestier Olivier, Di Pasquale Elisa, Pascal Géraldine, Persani Luca, Fabre Stéphane

Abstract excerpt

Bone Morphogenetic Protein 15 (BMP15) is a TGFβ-like oocyte-derived growth factor involved in ovarian folliculogenesis as a critical regulator of many granulosa cell processes. Alterations of the BMP15 gene have been found associated with different ovarian phenotypic effects depending on the species, from sterility to increased prolificacy in sheep, slight subfertility in mouse or associated with primary ovarian...

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Source

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Identifiers

PMID: 24147118
DOI: 10.1371/journal.pone.0078199
PMCID: PMC3797742

Genes

BMP15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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