Article
A regulatory role for the cohesin loader NIPBL in nonhomologous end joining during immunoglobulin class switch recombination.
The Journal of experimental medicine - 18 Nov 2013
Enervald Elin, Du Likun, Visnes Torkild, Björkman Andrea, Lindgren Emma, Wincent Josephine, Borck Guntram, Colleaux Laurence, Cormier-Daire Valerie, van Gent Dik C, Pie Juan, Puisac Beatriz, de Miranda Noel Fcc, Kracker Sven, Hammarström Lennart, de Villartay Jean-Pierre, Durandy Anne, Schoumans Jacqueline, Ström Lena, Pan-Hammarström Qiang
Abstract excerpt
DNA double strand breaks (DSBs) are mainly repaired via homologous recombination (HR) or nonhomologous end joining (NHEJ). These breaks pose severe threats to genome integrity but can also be necessary intermediates of normal cellular processes such as immunoglobulin class switch recombination (CSR). During CSR, DSBs are produced in the G1 phase of the cell cycle and are repaired by the classical NHEJ machinery....
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