New genetic insights highlight 'old' ideas on motor dysfunction in dystonia.

Abstract excerpt

Primary dystonia is a poorly understood but common movement disorder. Recently, several new primary dystonia genes were identified that provide new insight into dystonia pathogenesis. The GNAL dystonia gene is central for striatal responses to dopamine (DA) and is a component of a molecular pathway already implicated in DOPA-responsive dystonia (DRD). Furthermore, this pathway is also dysfunctional and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Corpus Striatum
• Share to Dopamine
• Share to Dystonia