Article
An intriguing shift occurs in the novel protein phosphatase 1 binding partner, TCTEX1D4: evidence of positive selection in a pika model.
PloS one - 1 Jan 2013
Korrodi-Gregório Luís, Margarida Lopes Ana, Esteves Sara L C, Afonso Sandra, Lemos de Matos Ana, Lissovsky Andrey A, da Cruz e Silva Odete A B, da Cruz e Silva Edgar F, Esteves Pedro José, Fardilha Margarida
Abstract excerpt
T-complex testis expressed protein 1 domain containing 4 (TCTEX1D4) contains the canonical phosphoprotein phosphatase 1 (PPP1) binding motif, composed by the amino acid sequence RVSF. We identified and validated the binding of TCTEX1D4 to PPP1 and demonstrated that indeed this protein is a novel PPP1 interacting protein. Analyses of twenty-one mammalian species available in public databases and seven Lagomorpha...
Topics
- Amino Acid Motifs
- Amino Acid Sequence
- Animals
- Base Sequence
- Dyneins
- Evolution, Molecular
- Lagomorpha
- Mutagenesis, Site-Directed
- Mutation
- Protein Phosphatase 1