Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The absence of mutations in homeobox candidate genes HOXA3, HOXB3, HOXD3 and PITX2 in familial and sporadic thyroid hemiagenesis.

Journal of pediatric endocrinology & metabolism : JPEM - 1 Mar 2014

Kizys Marina M L, Nesi-França Suzana, Cardoso Mirian G, Harada Michelle Y, Melo Maria Clara C, Chiamolera Maria Izabel, Dias-da-Silva Magnus R, Maciel Rui M B

Abstract excerpt

BACKGROUND: The molecular mechanisms leading to the formation of the two thyroid symmetrical lobes, which are impaired in thyroid hemiagenesis (TH), are little known. OBJECTIVE: The aim of this work was to search for mutations in thyroid developmental candidate genes HOXA3, HOXB3, HOXD3 and PITX2. METHODS: Total DNA from peripheral blood was extracted and then the entire coding region of all these genes was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA Primers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Homeobox

Share to Homeobox Protein PITX2

Share to Homeodomain Proteins

Share to Polymerase Chain Reaction

Share to Thyroid Dysgenesis

Share to Transcription Factors

Source

Identifiers

PMID: 24127533
DOI: 10.1515/jpem-2013-0289

Genes

HOXB3
HOXD3
PITX2
HOXA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The absence of mutations in homeobox candidate genes HOXA3, HOXB3, HOXD3 and PITX2 in familial and sporadic thyroid hemiagenesis.PMID 24127533Read ↗

NKX2-5 Variant in Two Siblings with Thyroid Hemiagenesis.Semantic proximity Read ↗

Compound heterozygous GLI3 variants in siblings with thyroid hemiagenesis.Semantic proximity Read ↗

Thyroid Hemiagenesis: Incidence, Clinical Significance, and Genetic Background.Semantic proximity Read ↗

Extreme phenotypic variability of thyroid dysgenesis in six new cases of congenital hypothyroidism due to PAX8 gene loss-of-function mutations.Semantic proximity Read ↗

Genetic analysis of the paired box transcription factor (PAX8) gene in a cohort of Polish patients with primary congenital hypothyroidism and dysgenetic thyroid glands.Semantic proximity Read ↗

Genetics and phenomics of hypothyroidism and thyroid dys- and agenesis due to PAX8 and TTF1 mutations.Semantic proximity Read ↗

Transcriptome, methylome and genomic variations analysis of ectopic thyroid glands.Semantic proximity Read ↗

Mutations in proteasome-related genes are associated with thyroid hemiagenesis.Semantic proximity Read ↗

Possible non-Mendelian mechanisms of thyroid dysgenesis.Semantic proximity Read ↗

Genetic Variability of the Paired Box Transcription Factor; PAX8 Gene: Guidance Towards Treatment Strategies in a Cohort of Congenital Hypothyroidism.Semantic proximity Read ↗

Genetic analysis of the <i>PAX8</i> gene in children with congenital hypothyroidism and dysgenetic or eutopic thyroid glands: identification of a novel sequence variantSemantic proximity Read ↗

Thyroid hemiagenesis is a rare variant of thyroid dysgenesis with a familial component but without Pax8 mutations in a cohort of 22 cases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.