Article
Post-transplant recurrence of atypical hemolytic uremic syndrome in a patient with thrombomodulin mutation.
Pediatric transplantation - 1 Dec 2013
Sinibaldi Serena, Guzzo Isabella, Piras Rossella, Bresin Elena, Emma Francesco, Dello Strologo Luca
Abstract excerpt
HUS is characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. While "typical" HUS is usually associated with Shiga toxin-producing Escherichia coli infections and recovers in the majority of cases, aHUS is caused by mutations of complement components or antibodies against CFH leading to uncontrolled activation of alternative complement pathway and often to ESRD. Recently, THBD gene...
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